Epigenetics and pharmaco-epigenetics in the primary headaches

Genetics, epigenetics and pharmaco-(epi)genomics in angiogenesis

Angiogenesis is controlled by a balance between pro- and anti-angiogenic factors. Studies in mice and human beings have shown that this balance, as well as the general sensitivity of the endothelium to these factors, is genetically pre-determined. In an effort to dissect this genetic basis, different types of genetic variability have emerged: mutations and translocations in angiogenic factors h...

The Prospects of Epigenetics in Neuroscience

Epigenetics and primary care.

Epigenetics, the study of functionally relevant chemical modifications to DNA that do not involve a change in the DNA nucleotide sequence, is at the interface between research and clinical medicine. Research on epigenetic marks, which regulate gene expression independently of the underlying genetic code, has dramatically changed our understanding of the interplay between genes and the environme...

The Role of Epigenetics in Cancer Drug Resistance

Cancer is caused by aberrant genetic and epigenetic changes in genes expression. DNA methylation, histone modification, and microRNAs gene deregulation are the most known epigenetic changes in different stages of cancer. Since every tumor has its own specific epigenome, any abnormal pattern is a potential biomarker for classification of different types of tumors. Despite, tumorigenesis, abnorma...

Epigenetics

By the time the reader reaches Chapter 20, which focuses specifically on cancer, the mechanisms and symptoms of cancer are relatively easy to understand. Chapter 20 covers topics such as the cellular phenotypes of cancer, genes linked to cancer, and cancer treatment. While the primary literature citations at the end of the chapter will provide good starting points for the curious student, a mor...